Editorial
Sophie Domingues-Montanari
Abstract
There has been a complete change in the diseases that impact our lives in the last century, with a shift away from infectious diseases to age-related disorders, such as of cancer, cardiovascular, and neurological diseases. Telomere shortening, mitochondrial changes, immune system regulation, cell senescence, and stem cells are routinely cited as major contributors to the extraordinary process of aging. In vitro and in vivo models have been invaluable, leading to new therapies and technologies. Transversal and longitudinal observational studies are now needed to establish the biochemical, genetic, and lifestyle factors that discriminate healthy from unhealthy aging.