Original Articles
M. M. Eswarudu, Vivek Joyal, D
Abstract
A simple, economical, accurate, precise and less time consuming UV spectrophotometric method has been developed and validated for the estimation of Eprosartan in bulk and pharmaceutical formulations. In this method Eprosartan exhibits maximum absorbance (λ max) at 233.The drug was obeys Beer’s law in the concentration range of 2-20μg/ml. The method was validated as per the International Conference on Harmonization (ICH) guidelines. Drug followed the linearity in the concentration range of 2-20μg/ml with correlation coefficient (r2) of 0.998. The validity of the proposed method was assessed by applying the standard addition technique where the percentage recovery of the added standard was found to be 98.68 ± 0.701 for Eprosartan Mesylate.The limit of detection and quantification were calculated to be 0.045386μg/ml and 0.0542916μg/ml respectively. The proposed method is recommended for routine analysis of eprosartan in bulk and its dosage forms in quality control testing laboratories. Hence it is rapid, simple, accurate and sensitive.