Validated method for Vinblastin by Spectrophotometry in Bulk Drug and Pharmaceutical formulations

C. M Bhaskar Reddy and G V Sub

Abstract

A simple, rapid and sensitive spectrophotometric me thod for the determination of vinblastine in p ure form and in pharmaceutical. Formulations is described .The meth od is based on the simple solubility of vinblastin e in methanol. The absorbance maximum of vinblastine measured at w ave length 420 nm. The drug obeys Beer’s Law in the concentration range 6-16 μ g/ml employed for this method. Accuracy and reprod ucibility of the proposed method was statistically validated by recovery studies. Th e method is found to be rapid, precise and accurate and can easily be employed in the laboratory for the routine estim ation of drug and it’s extended to the analysis of vinblastine in pharmaceutical formulations.