Use of electrochemical technics as a tool for the evaluation of the in vitro mutagenic potential of abamectin pesticide

I. Ghenabzia, T. Lanez, M. Did

Abstract

The aim of this study isto evaluate the mutagenic and/or the carcinogenic potential of the pesticide "abamectin" which largely used in agriculture in the region of El-Oued (South Algeria), the mutagenic and/or the carcinogenic potential was evaluated by the detection of the adduct formed from the reaction of the pesticide and nucleosides. The products of the reaction of abamectin with nucleosides at physiological conditions were detected and quantified by cyclic voltammetric measurements and confirmed using reverse-phase HPLC. Also, the obtained results showed that only thymidine (T) and deoxyadenosine (dA) nucleosides can form adducts with abamectin which confirm its mutagenic potential.