Research Article
Blake T. Dotta, Lukasz M. Karb
Abstract
A fast, inexpensive, and accurate method for differentiating normal (non-malignant) cells from malignant cells could facilitate diagnosis and subsequently treatment. Although blood constituents are the current dominant indicators, we have found that Spectral Power Densities (SPD) obtained from only 100 s of measurements of spontaneous ultra-weak photon emissions (UPE) from cell cultures significantly differentiated malignant from non-malignant states. Breast cells were particularly differentiable from nonbreast cells according to their SPD profiles. More critically the combination of only 3 discrete frequency increment changes in SPD profiles accurately classified 85% of malignant breast cells from normal breast cells in culture. These results confirm results from our mouse experiments and preliminary observations from our human measurements that appropriately analyzed and interpreted SPD from very brief samples of UPE may be a viable tool for early detection of malignancy.