Original Articles
Chengyuan Liang, Zhishu Tang,
Abstract
An expeditious and greener one-pot procedure was developed for the synthesis of multisubstituted 2-aminothiophene derivatives. In the presence of catalytic amount of DABCO, ketones or aldehydes, dicyanomethane and elemental sulfur were converted into the corresponding 2-aminothiophene derivatives in moderate to high yields in PEG-200 under sonication.