Twelve weeks consumption of fortified dairy product improves insulin like growth factor levels in older adults with sarcopenia: A double-blind randomized controlled trial.

Zahra Sohrabi

Abstract

Aging process is associated with altered anabolic hormones secretion (e.g., growth hormone, and insulin-like growth factor (IGF-1)) and increased pro-inflammatory cytokines which might lead to progressive decline in muscle mass and strength. Nutritional intervention might influence on sarcopenia progression through the anabolic stimuli of specific nutrients. Thus, this study evaluated the hypothesis that fortified yogurt might result in improvements in anabolic and inflammatory biomarkers. A total 66 sarcopenic older adults received either fortified yogurt contained 3 g HMB and 1000 IU vitamin D3) in the intervention group or plain yogurt in control group for 12 weeks. At baseline and after 12 weeks, serum concentrations of 25-hydroxy vitamin D, insulin like growth factor-1(IGF-1), C-reactive protein (hs-CRP), malondialdehyde (MDA) and insulin were measured. Homeostatic model assessment of insulin resistance (HOMA-IR) was also derived. After 12 weeks of intervention, significant increases in 25-(OH) vitamin D.