Short Communication
Daniela Hutanu and Costel C
Abstract
Characterization of PEGylated proteins in crucial in the biotechnology industry for quality control and formulation purposes. This mini review lists several Mass Spectrometry (MS) methods employed in the past 20 years for PEGylated protein analysis. The trend seems to shift from predominantly qualitative MALDI, to liquid chromatography coupled with MS for quantitative or conformational studies.