Original Articles
Bhadra Sulekha and Gajera Avin
Abstract
Silver sulfadiazine creams or ointments are used as antimicrobial agents in the treatment of second and third degree burns. But application by touching the wounded surface is painful and may spread secondary infection. The objective of the present study was to formulate topical spray for wound healing to provide more patient compliance and reduce the chances of further contamination or spread of infection at the site of wound. An aqueous spray formulation of silver sulfadiazine was prepared using HPMC E5LV as film forming polymer and PEG 200 as plasticizer. The concentrations of polymer and plasticizer were optimized by 32 full factorial design, considering film forming time, volume per spray, area of film, % cumulative drug release as dependent factors (responses). The optimized batch with drying time 332±4 Sec and % drug release 71±1.4% in 270 min., showed comparable in-vitro antimicrobial activity and wound healing capacity in Wistar rats with marketed formulation. Thus, a topical spray of Silver sulfadiazine can be used for effective treatment of open wounds.