Original Articles
Malek Lemsi, Mohamed Radhouan
Abstract
The thermal decomposition of Fluconazole-active substance and tablet were studied using differential scanning calorimetry (DSC) and thermogravimetry (TG). Thermal analysis was supplemented using X-ray powder diffraction and infrared spectroscopy to characterize samples. It was observed that the active substance showed a slight different thermogravimetric profile in commercial sample, due to the presence of the excipients in drug (tablet). DSC studies of binary mixtures, fluconazole and excipients (lactose monohydrate, microcrystalline cellulose and magnesium stearate) showed, with the exception of microcrystalline cellulose, that endothermic peaks of drug was broadened and shifted to lower temperature. These differences may be due to the small interactions that have not been confirmed by FT-IR spectroscopy. Through non-isothermal conditions, the activation energy for the decomposition reaction of Fluconazole active substance and tablet were determined. It was revealed the lower thermal stability of fluconazole-tablet compared with the active substance.