The role of L-carnitine and solanum nigrum as a food supplement and antioxidant against thiamethoxam-induced hepatotoxicity in male rats

Heba M. Abdou1, Nema A. Mohame

Abstract

This research was carried out to investigate the role of L.carnitine and Solanum nigrum seeds as food supplement and antioxidant against thiamethoxam induced hepatotoxicity in male rats. The present results showed insignificant decrease in the activity of ALT, AST, ALP, GGT, LDH enzymes and significant decrease in the concentration of total bilirubin in LC and SNS-treated group compared to control. Also, the present results showed significant increase in the values of ALT, AST, ALP, GGT, LDH and bilirubin after administration of TMX compared to the control group. While, the combination groups treated with LC + TMX or SNS + TMX revealed significant decrease in the values of ALT, AST, ALP, GGT, LDH and bilirubin as compared to TMX-treated group. Administration of LC or SNS alone showed insignificant increase in serum total protein, albumin, globulin and albumin /globulin ratio compared to control group. On the other hand, TMX-treatment caused significant decrease in the levels of total protein, albumin, globulin and albumin /globulin ratio compared to the control group. In comparison with TMX-treated group, administration of LC+TMX and SNS+TMX showed significant (P<0.05) increases in the serum levels of the total protein, albumin, globulin and albumin /globulin ratio. The values of cholesterol, triglycerides, LDL-C, VLDL-C and HDL-C were showed insignificant changes in LC-treated group and SNS-treated group compared to control group. The values of cholesterol, triglycerides, LDL-C, VLDL-C and HDL-C were significantly increased while, serum HDL-C was significantly decreased after administration of TMX compared to the control group. On the other hand, the combination of LC+TMX and SNS+TMX-treated groups showed significant decrease in the levels of cholesterol, triglyceride, LDL-C, VLDL-C while, the level of HDL-C was significantly increased compared to TMX-treated group. Oral administration of LC and SNS showed insignificant changes in TBARS, SOD, GPX and GR and significant increase in GSH levels as compared to the control group.