The protective effect of orange juice on glyphosate toxicity in adult male mice

Eman R. Youness, Fatma E. Agha

Abstract

Glyphosate is a broad spectrum herbicide. Fruits and vegetables improve health and a diminish chronic degenerative processes. This study aims to investigate orange juice protective role against the toxicity of glyphosate induced in mice. Fifty six adult male albino mice divided into seven groups. Oral administration of glyphosate caused a significant increase in MDA levels, serum AST, ALT, BUN, creatinine, CEA and DNA damage and decrease in serum testosterone levels. Treatment with orange juice combined with glyophosate for 2 and 4 weeks decrease the incidence of hepatotoxicity, nephrotoxicity, lipid peroxidation, genotoxicity and serum CEA in concomitant with significant elevation in serum testosterone levels compared to glyphosate- treated groups. Results proved that orange juice is a potent protector against glyphosate-induced toxicity, and its protective role is timedependent