The Potential Activity of Hydroxychavicol against Pathogenic Bacteria

Jangala Jesonbabu, Navuru Span

Abstract

Hydroxychavicol isolated from Piper betle leaves, showed inhibitory activity against gastrointestinal pathogens. It exhibited inhibitory effect on the entire gastrointestinal pathogens tested (MICs of 200-400 ?g/ml) with an MBC, which was twofold greater than the inhibitory concentration. Hydroxychavicol exhibited concentration dependent killing of Staphylococcus aureus and Escherichia coli to 4 x MIC, that the hydroxychavicol would be a useful compound for the development of antibacterial agents against gastro intestinal pathogens and has great potential for use in treatment of gastrointestinal infections.