Original Articles
Fatemeh Araste, Mohammad Ramez
Abstract
Several plant-derived drugs have been used in medical oncology till now. In this study the methanolic and aqueous extracts of Viburnum lantana were tested for possible antitumor activity using potato disc assay. To investigate the antimicrobial activity the minimum inhibitory concentration (MIC) of 0.01, 0.1 and 1 mg/ml of each extract against Agrobacterium tumefaciens was evaluated using microplate method. The antitumor activity of the extracts was evaluated with the potato disc assay. Both aqueous and methanolic extracts demonstrated no antibacterial activity. In potato disc assay a dose response correlation was observed between the extracts and the tumor growth inhibition. In conclusion, V. lantana methanolic and aqueous extracts did not exert inhibitory effects on bacterial growth, however, inhibition effect on the tumor growth observed in a dose-dependent manner. These results confirm the anti-tumor activity of V. lantana.