The Hollow Fiber Infection Model for Antimicrobial Pharmacodynamics and Pharmacokinetics

John J.S. Cadwell

Abstract

The recent introduction of hollow fiber bioreactor cartridges represents an important advancement in the field of in vitro toxicology. Many toxicologists believe in vitro testing methods are a useful, time and cost effective tool for drug discovery but it is generally accepted that many of the available tests are not effective for examining both time and concentration, and do not closely mimic human kinetics. This is because they do not properly take into account pharmacodynamic actions (what a drug does to the body) and pharmacokinetic actions (what a body does to the drug). Recently, with the use of hollow fiber bioreactor cartridges, this has changed. The hollow fiber infection model is a useful addition to standard in vitro toxicology methods as it mimics changes in drug concentration over time, as they would occur in humans. An overview of historic pk/pd models is presented and the utility of the hollow fiber infection model as it relates to antibiotics and other drugs are discussed.