The generation of anti-tumour bystander killing by genetically engineered ovarian tumour cells and the influence of ϒ-irradiation: Implications for clinical use as cancer vaccines

Jehad Zweiri

Abstract

Cellular based therapeutic approaches for cancer rely on careful consideration of finding the optimal cell to execute the cellular goal of cancer treatment. Cell lines and primary cell cultures have been used in some studies to compare the in vitro and in vivo efficacy of autologous vs allogeneic tumour cell vaccines. This study examines the effect of Υ-irradiation on a range of tumour cell lines in conjunction with suicide gene therapy of cancer. To determine the efficacy of this modality, a series of in vitro and in vivo experiments were conducted using genetically modified and unmodified tumour cell lines.