The evaluation of the effect of synthetic flavonoids on growth of pathogenic and probiotic bacteria

Boubakeur B., Tirtouil A., Med

Abstract

Biological properties of natural flavonoids were su cceeding great interest for the synthetic of new fl avonoids; recent publications were shown that these last have posses sed a various biological activities particularly: a ntimicrobial, anti-viral, anti-tumoral, and antihypertensive... The aim of this study was to assessment the effect of synthetic flavonoids on growth of probiotic (Lactobacillus rh amnosus and Streptococcus thermophilus) and pathoge nic (Staphylococcus aureus and Escherichia coli)bacteri a. All tested compounds were exhibited an antibacte rial and prebiotic effect; The 7-[3-N-(1,2-O-isopropylidène- α -D-xylofuranos-5-yl)-amino-2-hydroxypropoxyl]-8-mét hyl flavone (product 4) was found to have the most significant activity as antibacterial agents ; Regarding to the prebiotic activity, 7-[3-N-(D, L-glycéryl)-amino-2-hydroxypropoxy]-8-mé thylflavone (product 5) was the most active. The results suggest that these molecules ac count both the antimicrobial and prebiotic activiti es.