Ivan Kanev, Jennifer Grove, Ke
Abstract
Introduction: We spent over two decades in an effort to search and study the same electric charge properties of chromosomes that were doubted, rejected and ignored in main stream theories and concepts in genetics and molecular biology. Materials & Methods: All studies described in this publication were organized at the Human Genetics Laboratory, Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, USA. They provided chromosome materials, funding, technologies, consumptives and resources used in this study. Results & Discusssion: Our searching revealed previously unnoticed similarities,magic numbers, and Fibonacci like spiralsin the construction of chromosomes and previously undescribed structures and events related to the density, measurement ofelectric current, and model for the interactions between negatively charged DNA and positively charged histones. We use the charge of chromosomes to reveal issues and to propose solutions concerning six fundamentally important events and constituents in the construction and function of chromosomes:the purpose of nucleosomes; the importance of heterochromatin; the primary mission of packing DNA into chromosomes;missions and mechanisms for homologous chromosomes, crossing over,and information systems Conclusion: This publication presents novel ideas, findings and proposals concerning the electric charge property- related phenomena of chromosomes and their positive implications on the construction and function of chromosomes along with the negative effects that are responsible for the development of numerical and structural abnormalities of chromosomes seen in health conditions with a chromosomal etiology.