Short communication
Mehrnaz Ajorloo and Saeed Soro
Abstract
Cancer is a disease that ranks first in the world in terms of mortality and morbidity, and regardingly breast cancer that can be caused by environmental and genetic factors. Therefore, more detailed studies and studies on the effect of epigenetic factors in cancer. Breasts can lead to practical results in preventing and treating them. As we know, the set of controlled processes that cause hereditary changes in gene expression and mark the gene independent of a change in the nucleotide sequence of DNA is epigenetic. The direct or indirect factors in this process are the expression of microRNAs. They change in the cell, and amputation in these mechanisms certainly leads to the activation or inhibition of various messenger pathways and the development of cancer. Hypermethylation of epigenetic mechanisms in specific promoters can activate the expression of inappropriate oncogenes and act as a tumoral suppressor gene in breast cells in the hypermethylated form. More than 100 hypermethylene genes have been identified in breast tumors with breast cancer cell lines in recent research. Most of these methylated genes play an important role in the cell cycle of the apoptotic cell cycle. It is a cell, and its increasing expression inhibits the transition from G1 to S cell cycle. This gene is often found in breast cancer and is the first event in the development of this cancer.