The Effect of Cadmium on Iron Metabolism in Rats: A Combined Therapy by Deferasirox and Deferiprone

Seyed Mojtaba Mashmool Moqadam

Abstract

This study is aimed to evaluate the potential efficiency of deferasirox (DFX) and deferiprone (L1) as an oral drug chelators on the excretion of cadmium (Cd) in cadmium-poisoned wistar rats following drink administration. After a period of 60 days, all the rats administered cadmium were severely anemic and showed toxicity symptoms through loss of hair and increasing in cadmium and reduction in iron levels in blood. Our results showed that the effect of cadmium on hematological indices was statistically important and confirmed the iron deficiency anemia in rats. Chelation therapy period started immediately after cadmium administration during two weeks. The chelation therapy results showed that deferasirox and deferiprone were able to remove cadmium ions from the body while iron concentration returned to normal level and also iron deficiency anemia that caused by cadmium administration obviated.