Onwubuya Emmanuel Ikechuckwu,
Abstract
Bryophyllum pinnatum Lam.Oken (Crassulaceae) is widely used as food and as medicine in traditional medicine. The plant is found widely in tropical Africa, America, India and China. This study explores the bioactive compounds in the plant and investigates the effect of the hydro ethanol leaf extract on enzymes involved in the inflammatory pathways using GCMS and Cotton Pellet Induced Granuloma method. Results revealed that the hydro-ethanol leaf extract showed nine peaks, indicating nine bioactive compounds with 2-Amino-3-hydroxypyridine being highest (34.678%). Our findings indicated that the plant’s extract reduced inflammation in rats, causing a significant inhibition of inflammatory biomarkers (cyclooxygenases 1 and 2, interleukins 1β and 6 as well as prostaglandin E2) in a dose dependent manner. B. pinnatum leaf extract showed rich content of bioactive compounds which could be synthesized to produce new plant-based product to fight inflammatory disorders with fewer side effects.