Original Articles
Arun Kumar D, Revathy K, Rajes
Abstract
Divalent macrometals Calcium (Ca) and Magnesium (Mg) plays a significant role in the metabolism of carbohydrates, especially diverting assimilable glucose for utilization. Phosphate ions are essential during phorylation, a key enzyme reaction which diverts glucose to metabolic pathways. Urate, an end product of purine metabolism is altered in uncontrolled diabetes mellitus (DM) particularly in T2DM. As blood Glycosylated Hemoglobin (HbA1c) serves as an Index of long term Diabetic Control and is considered a gold standard, its level will indeed be associated with metals like Ca, Mg along with Phosphate and Urate, all of which are altered. Hence there must exist some association between HbA1c and Ca, Mg, P and Uric acid. Uric acid level is always low in DM and is associated with metabolic syndrome (metS) and serves as a potential biomarker for DM as its level is directly proportional to albuminuria. This study is an attempt to find out the association of HbA1c to Ca, Mg, P and Urate and to suggest that these 4 tests must be done for all T2DM patients.