Jibin Joy
Abstract
The homeostatic signaling system in Homo sapiens is highly complex involving diverse physiological processes which are what enables the biological regulation of life. Human body is a highly dynamic system, the normal functioning of which is coordinated and maintained by a well-established mechanism of homeostatic regulation. Disorder genesis and progression has an underlying disruption in homeostatic regulation, even though pathophysiology and clinical presentations may vary. Progressive neurodegenerative conditions are an outcome of disrupted homeostatic regulation, which triggers accumulation of dysfunctions and impairment of neuroplasticity. Ayurveda considers neurodegenerative conditions to be brought by the imbalance of 'Vata', the energy that moves through the brain and the nerves. The scholars behind classical ayurvedic literature considered neural impulses to be a kind of air traveling through the body, controlling both voluntary and involuntary functions. Oxygen is the real time mediator of homeostatic signaling system and defective oxygen transport; thereby impairment in oxygenation is the prime underlying factor in neurodegenerative conditions. The broad spectrum therapeutic effects demonstrated by Withania Somnifera or Ashwagandha are a result of its profound mechanism of enhancement of oxygenation. Also the ayurvedic branch of medicine known as 'Rasa Shastra' uses 'Bhasma', traditionally prepared Nano medicines, some of which shows influential enhancement in oxygenation.