The Activation Role of Protein Kinase D1 Important In Mitochondria and Oxidative Stress in Association with Pancreatic Cancer

Duraid Hamid Naji Al-Midfai P

Abstract

? A In this study, the mitochondrial efficiency and metabolic activity regulation of cancer cells were discussed, which revealed that the reactive oxygen species (ROS) plays the co-Related role with the generate cancer cells. For inhibition of cytotoxic and facilitating tumorigenic signals, mechanism of ROS must be controlled. The molecules signal that was rich to nucleus plays key rules in regulating antioxidant genes by  increased oxidative stress. ROS sensors have many proteins one of these proteins Protein kinase D1 (PKD1)  In this survey, we focus on the effect of ROS to activate the PKD1 as well as pancreatic cancer progress.