Tetrabutylammonium acetate catalyzed one-pot multi component synthesis of spirooxindoles from 1-methylquinoline-2,4(1H, 3H)-dione

Raja S. Bhupathi, Bandi Madhu,

Abstract

An efficient one pot synthesis of spirooxindoles by three-component reaction of isatin, malononitril/ethylcyano acetate and N-methylquinoline-2, 4-dione in water in the presence of TBA Acetate has been described. The methodology described here has the advantages of environment friendliness, higher yields, low cost, low reaction times and convenient operation