Research Article
P. Vedavathi, K. Chandra Sekha
Abstract
Amlodipine is one of the calcium channel blockers havingdihydropyridine group, used as an antihypertensive drug.A series of novel ureaandthioureaderivativesofamlodipine(1) were prepared by reacting (1) with various substituted isocyanates/isothiocyanates in the presence of triethylamine in THF at 50 °C. Their structures were established by IR, 1H, 13CNMR, Mass spectral data and C, H, N elemental analysis. Their antimicrobial activity was evaluated and the title compounds exhibited moderate antimicrobial activity.