Synthesis, spectral and thermal characterization of metal complexes derived from 4-((3,5-dibromo-2-hydroxy benzylidene) amino) benzene sulphonamide: In-vitro antimicrobial and anticancer activities

J. Anandakumaran, M. L. Sundar

Abstract

In this present work, we report the synthesis and characterization (IR, 1H NMR, 13C NMR, molar conductance, mass spectra, UV-Visible, thermal analysis, EPR, and Powder XRD) of Schiff base namely 4-((3, 5-dibromo-2-hydroxy benzylidene) amino) benzene sulphonamide and its metal complexes. The bidentate coordination of ligand through phenolic oxygen and imine nitrogen (-CH=N-) was confirmed using spectral data. With the help of TGA, number of water molecules in coordination sphere of complexes was predicted. The geometry of complexes was proposed using EPR spectra. In-vitro antimicrobial activity of compounds L, L-Cd, L-Cu, and L-Zn was evolved with five bacterial and two fungal strains, In-vitro anticancer activity toward HeLa (human cervical cancer cell) was carried out for compounds L, L-Cd, L-Cu, L-Zn and L-Mn, wherein, L-Cd shows potent inhibitory effect against HeLa cell line.