Synthesis, physicochemical and antimicrobial studies of Co(II), Zn(II) and Fe(III) mixed antibiotics metal complexes

I. Waziri, N. P. Ndahi and B.

Abstract

Some new transition metal complexes of Co(II), Zn(II) and F(III) with amoxicillin and cephalexin were prepared. The complexes were characterized based on melting point, solubility, conductivity, elemental analysis , IR and UV/Visible spectroscopy. Based on the data obtained, the complexes were proposed to have the formulae [M(A)(B)] where M= Co(II), Zn(II) , Fe(III) ; A= amoxicillin and B = cephalexin. The anti-microbial activities of the complexes / ligands using disc diffusion method was screened against different strains of bacteria; Staphlycoccus aureus, Strep pyogene, Bacillus subtilis, E.coli, Salmonella shigella, Klebsiella pneumonia, Pseudomonas auroginosa .The IR spectra indicates that both ligands A and B coordinated to the metal ion via v(C=O), v(O-H) and v(N-H) respectively. The UV/Visible electronic spectra further revealed that Co(II) and Fe(III) complexes are octahedral while that of Zn(II) is tetrahedral. The complexes melted/decomposed at (200-280)◦C. They are soluble in polar organic solvents. Anti-microbial activity studies, revealed that Co(II) complex showed increased activity against the tested organisms while Zn(II) and Fe(III) showed decreased activity as compared with the ligands.