Synthesis of Pectin Derivatives by Chain of Carboxylic Acids Esters Using Cross Esterification and Comparing the Pharmaceutical Properties as a Drug Delivery

Mohammad Keshe, Rushdi Madwar

Abstract

In this research, the chemical structure of the pectin was modified by reacted of carboxylic group in pectin with Fatty acid esters to change the hydrophilic properties of pectin by adding alkyl hydrophobic chains. Then, the effectiveness of drug release was studied by loading aspirin to forming beads for both of pectin and modified pectin containing the substance "aspirin" and comparing the time of release between pectin and modified pectin beads. The result showed an increase in the release time of drug substance by increasing the hydrophobic properties of alkylated The structures have been determined by spectroscopic methods: FT-IR, 1H-NMR.