Synthesis of Novel Substituted 4-[2-pyridylmethoxy]Phenyl Methylthio substiTuted Benzimidazoles and their Biological Activity

R Rajesh and N Nagaraju

Abstract

This work presents the synthesis of a few new substituted 4-[2-pyridylmethoxy] phenyl methylthio-substituted-benzimidazole (7a–l). Substituted 2-pyridylmethyl chlorides (1a–d) are condensed with 4-hydroxy-3-methoxy benzaldehyde (2) to yield substituted 4-[2-pyridylmethoxy] benzaldehyde (3a–d). These are further reduced to substituted 4-[2-pyridylmethoxy] benzyl alcohols (4a–d), and chlorinated to corresponding substituted 4-[2-pyridylmethoxy] benzyl chlorides (5a–d). These substituted 4-[2-pyridylmethoxy] benzyl chlorides are coupled with 2-mercapto-substituted-benzimidazoles to get substituted 4-[2-pyridylmethoxy] phenylmethylthio-substituted-benzimidazoles (6a–l). All the molecules thus synthesized were characterized by IR, 1H NMR, 13C NMR, 19F NMR & Mass spectral studies and screened for their anti-bacterial and anti-fungal activities.