Synthesis of novel quinazolinone-1,2,3-triazole conjugates

Gerda Krastina, Irisa Ravina,

Abstract

Hybrid compounds of 2-styryl quinazolinone and 1,2,3-triazoles were synthesized via 1,3-dipolar azide-alkyne cycloaddition reaction from 3-(2-azidoethyl)quinazolinones and various alkynes, followed by Knoevenagel reaction between 2-methylquinazolinone-1,2,3-triazole conjugates and aromatic aldehydes. All quinazolinone-1,2,3-triazole hybrid compounds were tested for their antiradical and antibacterial activity, but did not show any significant activity