Synthesis of novel amide derivatives of furo[3,2-c]pyridin-4-amine as potential antibacterial agents

N. Sree Lakshmana Raoa, K. R.

Abstract

The biological activities associated with furo[3,2-c]pyridine, the synthesis, spectroscopic identification and antibacterial activity of amide analogues (6a-6k) derived from 4-aminofuro[3,2-c]pyridine 5 in a few high yielding steps from commercially available 2-Furanldehyde (Scheme 1) is described. Amide derivatives of 4-aminofuro [3, 2-c] pyridine (6a-6k) was tested for antibacterial activity against Gram positive and Gram negative bacterial strains. The 1-methyl-pyrrole 6i, 1-methyl indole 6j and quinoline 6k moieties showed highest activity (inhibitory zone 19-23 mm) against both the Gram-negative bacteria and Gram-positive bacteria On the other hand, compounds 6e - 6h showed moderate activity (inhibitory zone 13-18 mm) and 6a - 6d showed weak activity (inhibitory zone 9 – 12 mm).