Synthesis of maleimide derivatives via CuAAC click chemistry and biological evaluation of their antitumor activity against cancer cell lines.

Guiqing Xu, Duanyang Kong, Wei

Abstract

A new series of maleimide derivatives bearing the 1,2,3-triazole moiety have been synthesized using the CuAAC reaction and evaluated for their cytotoxicity in vitro against human cervical carcinoma hela cell. The characterization of the target compounds was performed using IR, NMR, MS and HRMS. Most of the tested compounds showed potent activity toward the hela cell line. The most promising compound 6c showed excellent cytotoxicity with 16.7 µΜ of IC50 values. These findings might provide an alternative strategy for the development of novel anticancer agent.