Original Articles
Vaishali and Bahar Ahmed
Abstract
A series of 3-Phenyl-acrylic acid [1-(substituted-phenyl)-ethylidene]-hydrazide and 2-(substituted-phenyl)-2-methyl-5styryl-2, 3-dihydro-[1,3,4]oxadiazole were synthesize and evaluated for anticonvulsant activity. All compounds were docked on to (PDB ID: 4COF). Compound characterization carried out by IR, H1NMR, and Mass spectroscopy. All Compounds showed activity in the range of 40-90% comparison to Phenytoin. H-9, H10, O-9, and O-10 possess good significant activity. Compound 3-Phenyl-acrylic acid (2-oxo-1,2-diphenyl-ethylidene)-hydrazide(H-9) was the most active compound in docking study having Least Binding energy -7.4 Kcal/mol with Amino acid residues Ala 322, Ala 327, Cys 320, Glu 330, Leu 291, Phe 323, Ser 326, Thr 294, Val 287, Val 319, Val 324. MES (ED50=20.11) tests.