Synthesis Design of ‘Rivastigmine’-A Potent Therapeutic Agent for Alzheimer’s disease using Retrosynthetic Analysis

Chittaranjan Bhanja and Satyab

Abstract

Synthesis is an indispensable component in the multidisciplinary development process of small molecule pharmaceuticals. Designing synthetic routes to the pharmaceuticals by retrosynthetic analysis /synthon disconnection approach, developed by Prof.E.J.Corey of Harvard University has emerged as powerful means in synthetic organic/medicinal chemistry. Keeping a bird’s eye view on the works published in journals and patent literatures, some synthesis schemes have been proposed for a potent Alzheimer’s disease drug ‘Rivastigmine’ in a novel way basing on the retrosynthetic analysis. The proposed synthesis planning being a theoretical exploration, the actual laboratory execution requires the cross examination of a considerable number of factors such as reactions, reagents and order of events. In actual practice, generally that route is most feasible which satisfies the specific criterion for an ideal synthesis.