Synthesis, characterization, DFT/TDDFT calculation and superoxide dismutase activity of copper(II) complex with ligand derived from benzil and cysteine

Partha P. Biswasa, Pradip K. B

Abstract

The condensation product of benzil and amino acid cystein has been isolated and used to form mononuclear complex with Copper(II) (Cu(II)L). The ligand (L) has been characterised by – UV/visible, FT-IR, 1H and 13C NMR, ESI Mass spectroscopy etc. The Cu(II)L complex has been characterised by various spectroscopic techniques - UV/visible, FT-IR, ESI Mass, EPR and Thermo Gravimetric Analysis. The structure of Cu(II)L has been optimised by DFT calculation. TDDFT calculation has been performed to predict UV/Visible spectrum of Cu(II)L which is identical to the experimental one. Cyclic voltammogram showed quasi reversible behaviour with redox potential value -0.680 V at Platinum working electrode with Ag-AgCl (1 M NaCl) as reference electrode. Cu(II)L showed superoxide dismutase activity with IC50 value 7.8x10-6 M.