Synthesis, characterization and pharmacological studies of novel bis 1,3,4-oxadiazole and 1, 2,4-triazole derivatives

Shridhar. A. H1, J. Keshavayya

Abstract

A series of 2, 2’-(5-nitrobenzene-1, 3-diyl) bis (5-alkyl-1, 3, 4-oxadiazole) (2a-e) 5,5'-(5- nitrobenzene-1,3-diyl)bis(1,3,4-oxadiazole-2-thiol) (3) and 5,5'-(5-nitrobenzene-1,3-diyl)bis(4- amino-4H-1,2,4-triazole-3-thiol(5) were obtained via reaction of 5-nitro iso-phthalic dihydrazide (1). All these newly synthesized compounds were characterized by IR, NMR and Mass, spectral studies. Newly synthesized compound displayed potent antibacterial and antinociceptive activity.