Synthesis, characterization and microbicidal activity of novel heterocyclic compounds having 4-Thiazolidinones moiety

Viralkumar Modi and Kirtikumar

Abstract

reaction of Amino-aryl 1,3,4-oxadiazole derivatives into heterocyclic ring like 4-Thiazolidinone.All have studied the anti-inflammatory activity of 5-(6-methyl-2-substituted-4-pyrimidinyloxymethyl)-2,3-dihydro-1,3,4-oxadiazole-2- thiones relative to that of acetylsalicylic acid. The highest activity compounds appeared to be 5-(6-methyl-2- morpholino-4-pyrimidinyloxymethyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione and 5-(6-methyl-2-methylthio-4- pyrimidinyloxymethyl)-3-morpholinomethyl-2,3-dihydro-1,3,4-oxadiazole-2-thione.