Original Articles
Abhishek Mishra and V. S. Veli
Abstract
The application of inorganic chemistry to medicine is a rapidly developing field, and novel therapeutic and diagnostic metal complexes are now having an impact on medical practice [1], [2]. In this work, herbo-mineral complexes (of curcumin, Ferulic acid and Cinnamic acid) were synthesized with copper and zinc acetate salts. The method of synthesis was further optimized by altering one parameter at a time and keeping others constant. Purification of title compounds were performed by multiple washing with water and ethanol. The title compounds were characterized by UV, IR, Elemental analysis, inductively coupled plasma atomic emission spectroscopy (ICPAES), DSC and Karl Fischer analysis. Various physicochemical properties of title compounds were computed and compared with that of parent drug. To evaluate the changes in microbiological activity of parent drug after complexation, antibacterial studies were carried out and changes in MIC (minimum inhibitory concentration) of the complexes were compared with that of parent drug. It was thus observed that formation of complexes resulted in increase in antibacterial activity of parent drugs and MIC values were found to be decreased.