Research Article
Abhinav Kumar Jha, Parjanya Ku
Abstract
Literature survey reveals that thiazole moieties clubbed with triazoles have attracted considerable attention of medicinal chemists as they are endowed with a wide range of diverse biological activities such as antiinflammatory, analgesic, antimicrobial, anticonvulsant, anti-oxidant activity etc. Hence, the objective of present project is to synthesize and characterize newer analogues 3-[4-(substituted phenyl)-1,3-thiazol-2-ylamino]-4- (substituted phenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thiones and evaluate their anti-microbial and anti-fungal activity. A series of new thiazole clubbed with triazoles derivatives were prepared by condensation of Ethyl [4- (substituted phenyl)-1,3-thiazol-2-yl]carbamates and N-(substituted phenyl)hydrazinecarbothioamides. The structures of new compounds are supported by their IR, 1H NMR, MASS spectoscopy and Elemental analysis. All these compounds were screened for antimicrobial activity against Gram Positive, Gram Negative bacterial and fungal stains. All the compounds tested showed significant anti-fungal and antibacterial activity against the standard drugs used. Result showed better Antifungal activity in comparison to Antibacterial activity. Amongst the entire compound G1 (2-Nitro-phenyl substitution) showed most potent activity against fungus.