Synthesis, characterization and biological activity of salen-mixed ligand complexes with nickel(II), copper(II) and cobalt(III)

Akmal S. Gaballa

Abstract

Interaction of Schiff base compounds with metal ions and their metal complexes have been extensively investigated due to their wide range of applications in medicine and engineering [1-8]. In recent years, there has been a considerable interest in the chemistry of antipyrine and its derivatives such as 4-aminoantipyrine (AAP, Fig. 1) or their metal complexes. These compounds are reported to exhibit a wide range of applications in various fields like biological properties as antifungal, antibacterial, analgesic, sedative, antipyretic, anti-inflammatory agents, analytical and therapeutical [9-18]. Pyrrolidinedithiocarbamates (PDC) which represent a class of antioxidants mediate a wide variety of effects in biological systems [19]. It is a multipotent synthetic compound well known for its metal chelation property [20]. Also, ammonium pyrrolidinedithiocarbamate (APDC, Fig.1) has been used recently in various preconcentration and separation techniques [21-25]. APDC is most widely used to determine the metal ions that form slightly soluble complexes in an aqueous solution