Research Article
Raj Narayan Sharma1, K. P. Sha
Abstract
A series of new acid hydrazones have been synthesized by the reaction of Ethyl-2-[(N-cinnamoyl) 2, 3-dichloroanilido] acetohydrazide with various Carbonyl Compounds in 34 to 83 % yield. Hydrazones are white, brown and yellow colour solids, having high melting points. Newly synthesized compounds (1, 2, 3, 4, 5, 6, 7, 8, 9, 12, 13, 14, 15, 16 and 17) have been tested for their antibacterial activity against gram positive bacteria S.albus, S.aureus and gram negative bacteria E.Coli and Pseudomonas piosineus .The compound 2, 3, 5, 12, 13, 14, and 15 shown significant activity and compound 1, 4, 6, 7, 8, 9, 16 and 17 have shown moderate activity. The same compounds were tested for their antifungal activity against Candida albicans, Aspergillus Niger and Alternaria alternata at concentration of 30 mg/mL using savored dextrose agar media. The compound 2, 5, 12, 13, 14, and 15 shown significant activities and compound 1, 4, 8, 9, 16 and 17 have shown moderate activity against Candida albicans and Aspergillus Niger. All the other compounds did not show significant activity against the fungi at the concentration used. Some new compounds have been tested for antitubercular activity in-vitro using M. tuberculosis. The compounds were incorporated into Lowenstein Jensen egg medium having concentrations of 10 and 100 mg/mL and were inoculated with M. tuberculosis, H27, Rv strains, incubated at 370C and observed, the compound 03, 12, 13 (table-I) & 01 (table-II) inhibited the growth of M. tuberculosis at 100mg/mL concentration other compounds were found to be inactive