Synthesis, characterization and application of borax cross-linked carboxymethyl guar gum

Jay J. Patel, Mandar Karve, V.

Abstract

Control drug delivery is the new way to treat illness. Guar gum (GG) and its derivative viz. Carboxymethyl guar gum (CMGG) find its application in pharmaceutical formulation as binder and disintegrate agent. Further to extend its application second derivatization of CMGG was carried out to improve its properties. CMGG was cross-linked with borax and prepared derivatives was characterized by Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetry Analysis (TGA) and Scanning Electron Microscope (SEM). Prepared derivatives were used as drug binder in formulation of N-(4-hydroxyphenyl)acetamide (Paracetamol) and (RS)-2-(4-(2-methylpropyl)phenyl) propanoic acid (Ibuprofen). Tablets were prepared by wet granulation method. Prepared tablets were evaluated for hardness, friability, uniformity of weight content, uniformity of drug content and In-Vitro drug release studies.