Synthesis, Characterization and Antimicrobial Studies on a New Mannich Base N-(Morpholinomethyl)phthalimide and its Zinc(II), Cadmium(II) and Mercury(II) Complexes

M. Ramesha and A. Sabastiyanb

Abstract

The new Mannich base N-(morpholinomethyl)phthalimide (MMP) was prepared by Mannich condensation of morpholine, formaldehyde and phthalimide. The d10 transition metal complexes with this ligand were synthesized in non-aqueous media. The ligand and metal complexes were characterized on the basis of elemental analysis, molar conductance, UV, IR and NMR spectral studies. The bidentate chelation of MMP, bonding through carbonyl oxygen of the imide moiety and C-N-C of morpholine ring is suggested. Based on the IR, 1H NMR studies octahedral geometry is assigned for all the metal complexes. The ligand and the ZnII and CdII complexes were screened for their in vitro antibacterial and antifungal activities employing agar well diffusion technique. The complexes are more active than the ligand.