Research Paper
Arjunsingh K. Rana1, Sunil B.
Abstract
A series of 10 new N-acetyl pyrazolines (3a-3j) were synthesized from different chalcones of 5-(3-chloro-4- fluorophenyl) furan-2-carbaldehyde with hydrazine hydrate and acetic acid. The chemical structures of these compounds were confirmed by means of 1H NMR, IR and mass analyses. Newly synthesized compounds were screened in-vitro for their antimicrobial activity against varieties of bacterial strains such Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and fungi strain Aspergillus niger at 40 mg/mL. The resulted of compounds shown that chloro and flouro substituted pyrazoline derivatives are showing quite well activity as compare to the other functional groups.