Synthesis, characterization and antimicrobial activity studies of 2-(2-(5- benzoyl-1-H-1,2,3-benzotriazole-1-yl)2-oxoethylamino) acetic acid and their transition metal chelates

D.V. Parekh and P.S. Desai

Abstract

1-(5-benzoyl-1H-1,2,3-benzotriazole-1-yl)2-chloroethanone was condensed with 2-amino acetic acid ( Glycine ). The resulting 2-(2-(5-benzoyl-1H-1,2,3-benzotriazole-1-yl)2-oxoethylamino) acetic acid was characterized by elemental analysis and spectral studies. The transition metal chelates of the same were prepared with Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ and characterized by IR spectral studies and magnetic properties. The antimicrobial activity of ligand and its metal chelates were screened against various gram-positive (+) and gram-negative (─) organism. The results show that all these samples are more or less active agents against various organisms