Synthesis, Characterisation and Docking Studies of Metal(II) Complexes of Antiinflammatory drug Celecoxib

E. Vadivel and Karuna Umakant

Abstract

Co-ordination chemistry provides better opportunities to use metal complexes as therapeutic agents. These Co-ordination compounds show a wide variety of therapeutic action. Metal coordination can be used to improve the activity of biologically active molecules. Novel complexes of Cu(II), Co(II) and Ni(II) with Celecoxib (L) have been synthesized and characterized. The Celecoxib have a great attention because of its anti-inflammatory activity. The Celecoxib complexes were characterized by molar conductance, FTIR and UV-Vis. spectroscopy. Investigations of the infrared spectra of the celecoxib and their metal complexes indicated the vibrations due to–NH group are shifted with respect to the free molecule in line with their coordination to the metal. These complexes are formulated as [M(L)Cl2]. The molecular docking study of metal complexes was performed by using Autodock vina against Cyclooxygenase-II enzyme. The docking study revealed that metal complexes are potential inhibitors of Inflammation.