Research Article
Gunpreet Kaur, Sunil Kumar, As
Abstract
A series of novel benzimidazole analogs B1-B10 were synthesized by condensation of various 2- aryl/alkylbenzimidazole with 2-[4-(2-methypropyl) phenyl] propanoyl chloride obtained from 2-[4-(2-methylpropyl) phenyl] propanoic acid and thionyl chloride. All the synthesized compounds were screened for in vitro antimicrobial activities against Bacillus substilis, Staphylococcus aureus, Escherichia coli, Asperigilius niger and Candida albicans. Out of all prepared analogs compound B2 and B4 exhibits excellent antibacterial and anti fungal activity against Escherichia coli and Candida albicans respectively. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenin-induced paw oedema method in rats. The substituted benzimidazole derivatives B2, B3 and B4 show significant anti-inflammatory activity with reference to standard drug diclofenac sodium. The structures of the newly synthesized compounds were elucidated by using IR, 1H-NMR.