Synthesis, antibacterial, antifungal and antiinflammatory activities of 4-aryl-2-(4-chlorophenyl)-4H-pyrimido-[2,1-b][1,3]-benzothiazoles

ChaithanyaM. S., Nagendrappa G

Abstract

Anilines 1a-h on reaction with potassium thiocyanate and bromine in acetic acid yielded substituted 2-amino[2,1- b][1,3] benzothiazoles 3a-h. The compounds 3a-h on reaction with chalcone 4, yielded, 4-aryl-2-(4-chlorophenyl)- 4H-pyrimido-[2,1-b][1,3]benzothiaz oles. . Chalcone 4 was conveniently prepared by the reaction of 4- chloroacetophenone with benzaldehyde in the presence of sodium hydroxide. The newly synthesized compounds have been characterized by IR, 1HNMR, 13CNMR and mass spectral data. The compounds were then evaluated for antibacterial, antifungal and anti-inflammatory activities.