Research Article
Sanjay K. Patil and Hrushikesh
Abstract
The aim of present work is to synthesize new coumarin heterocycles and elucidates their biological activity. For the synthesis, methyl substituted 1,2,4-triazole coumarin molecule was treated with CS2gives coumarin isothiocyanate, which is used as precursor molecule. This resultant coumarin isothiocyanates further condensed with thioglycolic acid, glycine, anthranilic acid, o-amino thiophenol and o-aminophenol which forms various heterocyclic derivatives like 1,3-thiazolidin, 2-thioxoimidazolidin, quinazolin, benzothiazol and benzoxazol. The synthesized compounds were confirmed by the spectral techniques. All the compounds were screened for their antimicrobial activities and have been found to exhibited significant activities.